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CRPP Synapse & Trauma


Publications during CRPP 2019-2021 (CRPP members in bold type)

Rosi- Andersen, A.*, Meister, L.*, Graham. B., Bryant, R., Ehlers, A, Brown, S. & Kleim, B (in press). Circadian effects on intrusive re-experiencing in trauma survivors’ daily lives. European Journal of Psychotraumatology. (*equal contribution) NOTE: Awarded with a student poster prize at the Annual convention of the German-speaking society of Psychotraumatology (DeGPT), March 2021.

Xia Y, Melinščak F,  Bach DR (2021). Saccadic scanpath length: an index for human threat conditioning. Behavior Research Methods. DOI: 10.3758/s13428-020-01490-5

Bach D, Näf M, Deutschmann M, Tyagarajan SK, Quednow BB (2019). Threat Memory reminder under matrix metalloproteinase 9 inhibitor doxycycline globally reduces subsequent memory plasticity. J Neurosci. 14: 1285-19. DOI: 10.1523/JNEUROSCI.1285-19.2019

Noya SB, Colameo D, Brüning F, Mircsof D, Opitz L, Mann M, Tyagarajan SK*, Robles MS*, and Brown SA* (2019). The Cortical Synaptic Transcriptome is organized by Clocks, but its Proteome is Driven by Sleep. Science. 366: eaav2642. (*equal contribution). DOI: 10.1126/science.aav2642

Brüning F†, Noya SB†, Bange T, Rudolph JD, Cox J, Tyagarajan SK, Mann M, Brown SA*, and Robles MS* (2019). Rest-activity cycles drive dynamics of phosphorylation in cortical synapses. Science. 366: eaav3617. (*equal contribution)

Xia Y, Gurkina A & Bach DR (2019). Pavlovian-to-instrumental transfer after human threat conditioning. Learning & Memory, 26(5):167-175. DOI: 10.1101/lm.049338.119

Bach DR, Brown SA, Kleim B, Tyagarajan SK (2019). Extracellular matrix: a new player in memory maintenance and psychiatric disorder. Swiss Medical Weekly, 149, w20060. DOI: 10.4414/smw.2019.20060

Bach DR, Tzovara A, Vunder J (2018). Blocking human fear memory with the matrix metalloproteinase inhibitor doxycycline. Molecular Psychiatry, 23, 1584–1589. DOI: 10.1038/mp.2017.65

Other CRPP-relevant publications by individual teams 2019-2021 (Team members in bold type)

Shiva K. Tyagarajan

Tsai Y-C, Hleihil M, Cramer T, Ferrari KD, Barrett M, Bosshard G, Weber B, Stobart JL,Tyagarajan SK. Differential impact of GABAA Receptors on Inhibitory connectivity for Superficial Pyramidal Neuron Responsiveness In Vivo. (Cell Reports, under review) BioRxiv, 

Oostrum MV, Campbell B, Müller M, Pedrioli PGA, Tyagarajan SK, Wollscheid B (2020). Surfaceome dynamics during neuronal development and synaptic plasticity reveal system-wide surfaceome reoganisation independent of global proteostasis. Nat Commun. Nov 6;11(1):5741. doi: 10.1038/s41467-020-19654-4. DOI: 10.1038/s41467-020-18494-6

Campbell B and Tyagarajan S.K. Cellular mechanisms contributing to the functional heterogeneity of GABAergic synapses (2019). Front Mol Neurosci. 12: 187. DOI: 10.3389/fnmol.2019.00187

Steven A. Brown

Collins .B., Pierre-Ferrer S., Muheim C., Lucacsovitch D., Cai Y., Spinnler A., Herrera C.G., Wen S., Winterer J., Belle M.D.C., Piggins H.D., Hastings M., Loudon A., Yan J., Foldy C., Adamantidis A., Brown S.A. (2020) Circadian VIPergic neurons of the suprachiasmatic nuclei sculpt the sleep-wake cycle. Neuron 108:1-14. DOI: 10.1016/j.neuron.2020.08.001 PDF (PDF, 4 MB)

Muheim C., Spinnler A., Sartorius T., Dürr R., Huber R., Kabagema C., Ruth P., and Brown S.A. (2019) Dynamic and frequency-specific regulation of sleep oscillations by cortical potassium channels. Current Biology 29(18):2983-2992.e3. DOI: 10.1016/j.cub.2019.07.056

Miladinović Đ.*, Muheim C., Bauer S., Spinnler A., Noain D., Bandarabadi M., Gallusser B., Krummenacher G., Baumann C., Adamantidis A., Brown S.A.*, Buhmann J.M. (2019) SPINDLE: End-to-end learning from EEG/EMG to extrapolate animal sleep scoring across experimental settings, labs and species. PLoS Comput Biol. 15(4):e1006968. *co-corresponding DOI: 10.1371/journal.pcbi.1006968

Birgit Kleim

Grueschow M, Stenz N, Thörn H, Ehlert U, Breckwoldt J, Brodmann M, Exadaktylos A, Bingisser R, Ruff C, Kleim B. Real-world stress resilience is associated with the responsivity of the locus coeruleus. Nat Commun, in press [NCOMMS-19-29940C]

Paersch C, Schulz A, Wilhelm FH, Brown AD, Kleim B. Recalling autobiographical self-efficacy episodes boosts reappraisal-effects on negative emotional memories. Emotion. 2021 Feb 25. doi: 10.1037/emo0000949.  DOI: 10.1037/emo0000949

Wilhelm I, Azza Y, Brennwald K, Ehrt-Schäfer Y, Seifritz E, Kleim B. Investigating the effect of a nap following experimental trauma on analogue PTSD symptoms. Sci Rep. 2021 Feb 25;11(1):4710. doi: 10.1038/s41598-021-83838-1. DOI: 10.1038/s41598-021-83838-1

Xu Y, Vandeleur C, Müller M, Seifritz E, Kleim B, von Känel R, Wagner EN, Strippoli MF, Castelao E, Gholamrezaee MM, Preisig M, Ajdacic-Gross V. Retrospectively assessed trajectories of PTSD symptoms and their subsequent comorbidities. J Psychiatr Res. 2021 Feb 2;136:71-79. DOI: 10.1016/j.jpsychires.2021.01.049

Kube, T., Berg, M., Kleim, B. & Herzog, P. (2020). Rethinking post-traumatic stress disorder – A predictive processing perspective. Neuroscience and Biobehavioral Reviews. DOI: 10.1016/j.neubiorev.2020.04.014

Azza Y, Grueschow M, Karlen W, Seifritz E, Kleim B. (2020). How stress affects sleep and mental health: Nocturnal heartrate increases during prolonged stress and interacts with childhood trauma exposure to predict anxiety. Sleep. DOI: 10.1093/sleep/zsz310

Azza, Y., Wilhelm, I. & Kleim, B. (2020). Effect of sleep early post-trauma on intrusive memories. European Psychologist.

Grueschow M, Jelezarova I, Westphal M, Ehlert U, Kleim B. (2020). Emotional conflict adaptation predicts intrusive memories. PLoS One, 20;15(2). DOI: 10.1371/journal.pone.0225573

Ney LJ, Hsu CMK, Nicholson E, Zuj DV, Clark L, Kleim B, Felmingham KL.(2020). The Effect of Self-Reported REM Behavior Disorder Symptomology on Intrusive Memories in Post-Traumatic Stress Disorder. Behavioral and Sleep Medicine, 27:1-14. DOI: 10.1080/15402002.2020.1722127

Kleim, B., Horn AB, Kraehenmann R, Mehl MR, Ehlers A. (2019). Early Linguistic Markers of Trauma-Specific Processing Predict Post-trauma Adjustment. Frontiers of Psychiatry, 5;9:645. DOI: 10.3389/fpsyt.2018.00645

Hsu,  C.K., Kleim B, Nicholson EL, Zuj DV, Cushing PJ, Gray KE, Clark L, Felmingham KL. (2019). Sex differences in intrusive memories following trauma. PLoS One.;13(12):e0208575. DOI: 10.1371/journal.pone.0208575

Bolsinger, J., Seifritz, E., Kleim, B. & Manoliu, A. (2019). Neurobiological correlates of resilience in fMR studies in survivors of trauma: A comprehensive review. Frontiers in Psychiatry.

Kleim, B & Kalisch, R. (2019). Who stays resilient? The problem of predicting resilience. Nervenarzt, 89(7):754-758. DOI: 10.1007/s00115-018-0551-z

Woud, M. L., Kleim, B., & Cwik, J. C. (2019). Editorial for the Special Issue on negative appraisals in trauma: Current status and future directions for research. Cognitive Therapy and Research, 43, 139-142.

Dominik Bach

Bach DR, Melinščak F, Fleming SM, Voelkle M (2020). Calibrating the experimental measurement of psychological attributes. Nature Human Behaviour, 4, 1229-1235. DOI: 10.1038/s41562-020-00976-8

Homan P, Lau HL, Levy I, Raio CM, Bach DR, Carmel D, Schiller S (2021). Evidence for a minimal role of stimulus awareness in reversal of threat learning. Learning & Memory, in press. DOI: 10.1101/lm.050997.119

Privratsky AA, Bush KA, Bach DR, Hahn EM, Cisler JM (2020). Filtering and model-based analysis independently improve skin-conductance response measures in the fMRI environment: validation in a sample of women with PTSD. International Journal of Psychophysiology, 158, 86-95. DOI: 10.1016/j.ijpsycho.2020.09.015

Zimmermann J, Bach DR (2020). Impact of a reminder/extinction procedure on threat-conditioned pupil size and skin conductance responses. Learning & Memory, 27, 164-172. DOI: 10.1101/lm.050211.119

Melinščak F, Bach DR (2020). Computational optimization of associative learning experiments. PLOS Computational Biology, 16 ,e1007593. DOI: 10.1371/journal.pcbi.1007593

Staib M, Abivardi A, Bach DR (2020). Primary auditory cortex representations of fear-conditioned musical sounds. Human Brain Mapping, 41, 882-891. DOI: 10.1002/hbm.24846

Oberrauch S, Sigrist H, Sautter E, Gerster S, Bach DR, Pryce CR (2019). Establishing operant conflict tests for the translational study of anxiety in mice. Psychopharmacology, 236, 2527-2541. DOI: 10.1007/s00213-019-05315-y

Tzovara T, Meyer SS, Bonaiuto JJ, Abivardi A, Dolan RJ, Barnes GR, Bach DR (2019). High-precision magnetoencephalography for reconstructing amygdalar and hippocampal oscillations during prediction of safety and threat. Human Brain Mapping, 40, 4114-4129. DOI: 10.1002/hbm.24689

Ojala K, Bach DR (2020). Measuring learning in human classical threat conditioning: translational, cognitive and methodological considerations. Neuroscience and Biobehavioral Reviews, 114, 96-112. DOI: 10.1016/j.neubiorev.2020.04.019

Bach DR, Melinščak F (2020). Psychophysiological modelling and the measurement of fear conditioning. Behaviour Research and Therapy, 127, 103576. DOI: 10.1016/j.brat.2020.103576

Fullana MA, Dunsmoor JE, Schruers KRJ, Savage HS, Bach DR, Harison BJ (2019). Human fear conditioning: From neuroscience to the clinic. Behaviour Research and Therapy, 124, 103528. DOI: 10.1016/j.brat.2019.103528